Cat. No. 2895
Chemical Name: 5-(4-Fluorophenyl)-1-[4-(methylsulf
Biological ActivitySelective cyclooxygenase 2 (COX-2) inhibitor (IC50 values are 0.04 and >100 μM for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Williams et al (2001) A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established colon cancer xenografts. Neoplasia 3 428. PMID: 11687954.
Gierse et al (1996) A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 271 15810. PMID: 8663121.
Seibert et al (1994) Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc.Natl.Acad.Sci.USA 91 12013.
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Keywords: SC 58125, supplier, Selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, Oxygenases, Oxidases, SC58125, Pfizer, Tocris Bioscience, Cyclooxygenase Inhibitor products
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