(R)-(+)-HA-966

Cat. No. 0281

(R)-(+)-HA-966 C4H8N2O2 [123931-04-4]

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Chemical Name: (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one

Biological Activity

Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier. Also available as part of the NMDA Receptor - Glycine Site Tocriset™. S-enantiomer (Cat. No. 0282) available.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M.Wt:
116.12
Formula:
C4H8N2O2
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
123931-04-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Kemp and Priestley (1991) Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in cat cultured cortical neurons. Mol.Pharmacol. 39 666. PMID: 1674587.

Pullan et al (1991) Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966). Eur.J.Pharmacol. 208 25. PMID: 1834473.

Pullan et al (1990) Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex. J.Neurochem. 55 1346. PMID: 1975835.

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Keywords: (R)-(+)-HA-966, supplier, Partial, NMDA, agonists, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, merck, Tocris Bioscience, NMDA Receptor Agonist products

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