4-Methylhistamine dihydrochloride

Cat. No. 2342

4-Methylhistamine dihydrochloride C6H11N3.2HCl [36376-47-3]

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Chemical Name: 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride

Biological Activity

Potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

Technical Data

M.Wt:
198.09
Formula:
C6H11N3.2HCl
Solubility:
Soluble to 50 mM in water
Storage:
Desiccate at RT
CAS No:
36376-47-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Gbahou et al (2006) Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol 147 74.

Lim et al (2005) Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J.Pharmacol.Exp.Ther. 314 1310. PMID: 15947036.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 4-Methylhistamine dihydrochloride include:

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149. PMID: 23626477.

Do you know of a great paper that uses 4-Methylhistamine dihydrochloride from Tocris? If so please let us know.

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Keywords: 4-Methylhistamine dihydrochloride, supplier, Selective, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H4 Receptor Agonist products

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