Cat. No. 2342
Chemical Name: 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride
Biological ActivityPotent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gbahou et al (2006) Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol 147 74.
Lim et al (2005) Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J.Pharmacol.Exp.Ther. 314 1310. PMID: 15947036.
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Citations are publications that use Tocris products. Selected citations for 4-Methylhistamine dihydrochloride include:
Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149. PMID: 23626477.
Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Bone Joint Res 152 891. PMID: 17891168.
Do you know of a great paper that uses 4-Methylhistamine dihydrochloride from Tocris? If so please let us know.
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Keywords: 4-Methylhistamine dihydrochloride, supplier, Selective, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H4 Receptor Agonist products