H-9 dihydrochloride

Cat. No. 0396

H-9 dihydrochloride C11H13N3O2S.2HCl [116700-36-8]

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Chemical Name: N-(2-Aminoethyl)-5-isoquinolinesulfonamide dihydrochloride

Biological Activity

Protein kinase inhibitor. Inhibits PKA (Ki = 1.9 μM), PKG (Ki = 0.9 μM), CaMK II (Ki = 60 μM), PKC (Ki = 18 μM), casein kinase I (Ki = 110 μ M) and casein kinase II (Ki > 300 μM).

Technical Data

M.Wt:
324.22
Formula:
C11H13N3O2S.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
116700-36-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377. PMID: 1605572.

Hidaka et al (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23 5036. PMID: 6238627.

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Keywords: H-9 dihydrochloride, supplier, Protein, kinase, inhibitors, inhibits, Broad, Spectrum, Kinases, Tocris Bioscience, Broad Spectrum Protein Kinase Inhibitor Inhibitor products

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