H-7 dihydrochloride

Cat. No. 0542

H-7 dihydrochloride C14H17N3O2S.2HCl [108930-17-2]

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Chemical Name: (±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride

Biological Activity

Protein kinase inhibitor. IC50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μM respectively.

Technical Data

M.Wt:
364.29
Formula:
C14H17N3O2S.2HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
108930-17-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Quick et al (1992) The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source. Biochem.Biophys.Res.Commun. 187 657. PMID: 1530632.

Ratz et al (1990) Effect of the kinase inhibitor, H-7, on stress, crossbridge phosphorylation, muscle shortening and inositol phosphate production in rabbit arteries. J.Pharmacol.Exp.Ther. 252 253. PMID: 2299593.

Hidaka et al (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23 5036. PMID: 6238627.

If you know of a relevant reference for H-7 dihydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for H-7 dihydrochloride include:

Barcomb et al (2013) Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Front Mol Neurosci 84 834. PMID: 24056996.

Belmeguenai and Hansel (2005) A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation. Mol Pharmacol 25 10768. PMID: 16291950.

Do you know of a great paper that uses H-7 dihydrochloride from Tocris? If so please let us know.

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Keywords: H-7 dihydrochloride, supplier, Protein, kinase, Broad, Spectrum, inhibitors, inhibits, Tocris Bioscience, Broad Spectrum Protein Kinase Inhibitor Inhibitor products

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