Cat. No. 0234
Chemical Name: 1,2,5,6-Tetrahydropyridine-3-carbox
Biological ActivitySpecific GABA uptake inhibitor. IC50 values are 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219. PMID: 7851497.
Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377. PMID: 670980.
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Citations are publications that use Tocris products. Selected citations for Guvacine hydrochloride include:
Edwards et al (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 1808 260. PMID: 20691150.
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Keywords: Guvacine hydrochloride, supplier, Specific, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, Tocris Bioscience, GABA Inhibitor products