Guvacine hydrochloride

Cat. No. 0234

Guvacine hydrochloride C6H9NO2.HCl [6027-91-4]

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Chemical Name: 1,2,5,6-Tetrahydropyridine-3-carboxylic acid hydrochloride

Biological Activity

Specific GABA uptake inhibitor. IC50 values are 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.

Technical Data

M.Wt:
163.6
Formula:
C6H9NO2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
6027-91-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219. PMID: 7851497.

Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377. PMID: 670980.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Guvacine hydrochloride include:

Edwards et al (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 1808 260. PMID: 20691150.

Do you know of a great paper that uses Guvacine hydrochloride from Tocris? If so please let us know.

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Keywords: Guvacine hydrochloride, supplier, Specific, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, Tocris Bioscience, GABA Inhibitor products

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