GR 135531

Cat. No. 0896

GR 135531 C14H17N3O3 [190277-13-5]

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Alternative Name: 5-MCA-NAT

Chemical Name: 5-Methoxycarbonylamino-N-acetyltryptamine

Biological Activity

Binds with high affinity to MT3 melatonin sites in hamster brain, and low affinity (and no efficacy) at MT1 and MT2 melatonin receptors and thus can be used to discriminate between the melatonin receptor subtypes.

Technical Data

M.Wt:
275.31
Formula:
C14H17N3O3
Solubility:
Soluble to 100 mM in ethanol
Purity:
>97 %
Storage:
Store at RT
CAS No:
190277-13-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Lucchelli et al (1997) Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br.J.Pharmacol. 121 1775. PMID: 9283717.

Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for GR 135531 include:

Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179. PMID: 21091649.

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View Related Products by Product Action

Keywords: GR 135531, supplier, High, affinity, melatonin, MT3, ligands, Receptors, GR135531, 5MCANAT, Tocris Bioscience, Melatonin Receptor Ligand products

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