Cat. No. 0896
Alternative Name: 5-MCA-NAT
Chemical Name: 5-Methoxycarbonylamino-N-acetyltryp
Biological ActivityBinds with high affinity to MT3 melatonin sites in hamster brain, and low affinity (and no efficacy) at MT1 and MT2 melatonin receptors and thus can be used to discriminate between the melatonin receptor subtypes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Lucchelli et al (1997) Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br.J.Pharmacol. 121 1775. PMID: 9283717.
Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for GR 135531 include:
Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179. PMID: 21091649.
Do you know of a great paper that uses GR 135531 from Tocris? If so please let us know.
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Keywords: GR 135531, supplier, High, affinity, melatonin, MT3, ligands, Receptors, GR135531, 5MCANAT, Tocris Bioscience, Melatonin Receptor Ligand products
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