Cat. No. 0896
Alternative Name: 5-MCA-NAT
Chemical Name: 5-Methoxycarbonylamino-N-acetyltryp
Biological ActivityBinds with high affinity to MT3 melatonin sites in hamster brain, and low affinity (and no efficacy) at MT1 and MT2 melatonin receptors and thus can be used to discriminate between the melatonin receptor subtypes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lucchelli et al (1997) Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br.J.Pharmacol. 121 1775. PMID: 9283717.
Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.
If you know of a relevant reference for GR 135531 please let us know.
Citations are publications that use Tocris products. Selected citations for GR 135531 include:
Loma et al (2015) Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability. J Neurosci 172 1045. PMID: 25297531.
Crooke et al (2013) Melatonin and its analog 5-methoxycarbonylamino-N-acetyltryptamine potentiate adrenergic receptor-mediated ocular hypotensive effects in rabbits: significance for combination therapy in glaucoma. J Pharmacol Exp Ther 346 138. PMID: 23591996.
Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179. PMID: 21091649.
Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. Br J Pharmacol 336 127. PMID: 20959363.
Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Pharmacol Exp Ther 108 625. PMID: 11518737.
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Keywords: GR 135531, supplier, High, affinity, melatonin, MT3, ligands, Receptors, GR135531, 5MCANAT, Tocris Bioscience, Melatonin Receptor Ligand products
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