A 80426 mesylate
Cat. No. 2341
Chemical Name: N-Methyl-N-[[(1R)-1,2,3,4-tetrahydr
Biological ActivityHigh affinity α2-adrenoceptor antagonist and selective 5-HT uptake inhibitor (Ki values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Giardina et al (1995) A-80426, a potent and selective β2-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: II. Pharmacology profile. Drug Devel.Res. 35 246.
Meyer et al (1995) Synthesis and pharmacological characterisation of A-80426: a putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition. Bioorg.Med.Chem.Letts. 5 2287.
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Selective, high affinity, non-competitive α1A adrenoceptor antagonist
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