A 80426 mesylate
Cat. No. 2341
Chemical Name: N-Methyl-N-[[(1R)-1,2,3,4-tetrahydr
Biological ActivityHigh affinity α2-adrenoceptor antagonist and selective 5-HT uptake inhibitor (Ki values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Giardina et al (1995) A-80426, a potent and selective β2-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: II. Pharmacology profile. Drug Devel.Res. 35 246.
Meyer et al (1995) Synthesis and pharmacological characterisation of A-80426: a putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition. Bioorg.Med.Chem.Letts. 5 2287.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses A 80426 mesylate from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: A 80426 mesylate, supplier, High, affinity, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, a2-adrenergic, α2-Adrenergic, alpha2-Adrenergic, antagonists, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, A80426, Tocris Bioscience, Adrenergic α2 Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Selective, high affinity, non-competitive α1A adrenoceptor antagonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.