Cat. No. 0864
Chemical Name: 3-[3-(2-Dimethylaminoethyl)-1H-indo
Biological Activity5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands.
Licensing InformationSold with the permission of GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
on-line. Please contact Customer Service
References are publications that support the products' biological activity.
Clitherow et al (1994) Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J.Med.Chem. 37 2253. PMID: 8057272.
Skingle et al (1994) Stimulation of central 5-HT1D receptors causes hypothermia in the guinea pig. J.Psychopharmacol. 8 14.
If you know of a relevant reference for GR 46611 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses GR 46611 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: GR 46611, supplier, 5-HT1D, agonists, Serotonin, Receptors, GR46611, GlaxoSmithKline, GSK, Tocris Bioscience, 5-HT1D Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Potent 5-HT1A partial agonist and SSRI; antidepressant
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.