WEB 2086

Cat. No. 2339

WEB 2086 C22H22N5O2SCl [105219-56-5]

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Alternative Name: Apafant

Chemical Name: 4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine

Biological Activity

Potent, selective platelet-activating factor (PAF) receptor antagonist (Ki = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.

Technical Data

M.Wt:
455.96
Formula:
C22H22N5O2SCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
105219-56-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Cellai et al (2006) Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. Br.J.Cancer 94 1637. PMID: 16721373.

Sariahmetoglu et al (1998) Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats. Pharmacol.Res. 38 173. PMID: 9782066.

Dent et al (1989) Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086. FEBS Lett. 244 365. PMID: 2537761.

If you know of a relevant reference for WEB 2086 please let us know.

Citations are publications that use Tocris products. Selected citations for WEB 2086 include:

Yagnik (2014) Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation. Int J Inflam 2014 526496. PMID: 25328755.

Zhao et al (2013) Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. Br J Pharmacol 8 e82683. PMID: 24367540.

Ajiro et al (2011) Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. PLoS One 301 H2395. PMID: 21949111.

Al-Shawaf et al (2010) Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids. Arterioscler Thromb Vasc Biol 30 1453. PMID: 20378846.

Do you know of a great paper that uses WEB 2086 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: WEB 2086, supplier, Potent, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, WEB2086, Tocris Bioscience, Platelet-Activating Factor (PAF) Receptor Antagonist products

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