Trequinsin hydrochloride

Cat. No. 2337

Trequinsin hydrochloride C24H27N3O3.HCl [78416-81-6]

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Alternative Name: HL-725

Chemical Name: 2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride

Biological Activity

Extremely potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models.

Technical Data

M.Wt:
441.95
Formula:
C24H27N3O3.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>97 %
Storage:
Desiccate at RT
CAS No:
78416-81-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Agarwal et al (1987) Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences. Thromb.Res. 47 191. PMID: 2821650.

Lal et al (1984) Trequinsin, a potent new antihypertensive vasodilator in the series of 2-(arylimino)-3-alkyl-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-ones. J.Med.Chem. 27 1470. PMID: 6492077.

Ruppert and Weithmann (1982) HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro. Life Sci. 31 2037. PMID: 6294426.

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Keywords: Trequinsin hydrochloride, supplier, Ultrapotent, inhibitors, inhibits, PDE3, Phosphodiesterases, HL725, Tocris Bioscience, Phosphodiesterase Inhibitor products

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