D15

Cat. No. 2334

D15 Pro-Pro-Pro-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-Pro-Gly

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Biological Activity

Endocytosis inhibitor that blocks the interaction of dynamin with amphiphysin 1 and 2. Impairs AMPA receptor cycling and blocks DHPG-induced long term depression (LTD).

Technical Data

M.Wt:
1566.78
Formula:
C69H111N23O19
Sequence:
PPPQVPSRPNRAPPG
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
251939-41-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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Xiao et al (2001) Metabolic glutamate receptor activation causes a rapid redistribution of AMPA receptors. Neuropharmacology 41 664. PMID: 11640920.

Lüscher et al (1999) Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 24 649. PMID: 10595516.

Wigge and McMahon (1998) The amphiphysin family of proteins and their role in endocytosis at the synapse. Trends Neursci. 21 339.

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View Related Products by Product Action

Keywords: D15, supplier, Endocytosis, blockers, impairs, AMPA, receptor, cycling, dynamin, amphiphysin, 1, 2, Tocris Bioscience, Translocation, Exocytosis & Endocytosis products

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