Cat. No. 2330
Chemical Name: 10,10-bis[(2-Fluoro-4-pyridinyl)met
Biological ActivityK+ channel blocker and acetylcholine release stimulator. Potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and also increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Earl et al (1998) 2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action. J.Med.Chem. 41 4615. PMID: 9804701.
Zaczek et al (1998) Two new potent neurotransmitter release enhancers, 10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-Bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 285 724. PMID: 9580619.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses DMP 543 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: DMP 543, supplier, K+, channels, blockers, potent, ACh, release, enhancer, Potent, orally, active, Potassium, Channels, Non-Selective, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, DMP543, Tocris Bioscience, Non-selective / Other Potassium Channel Blocker products