Ro 10-5824 dihydrochloride

Cat. No. 2329

Ro 10-5824 dihydrochloride C17H20N4.2HCl [189744-94-3]

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Chemical Name: 5-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-4-pyrimidinamine dihydrochloride

Biological Activity

Selective dopamine D4 receptor partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM). Displays 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors.

Technical Data

M.Wt:
353.29
Formula:
C17H20N4.2HCl
Solubility:
Soluble to 100 mM in water and to 75 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
189744-94-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Powell et al (2003) RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology 44 473. PMID: 12646284.

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Keywords: Ro 10-5824 dihydrochloride, supplier, Selective, D4, receptor, partial, agonists, Dopamine, Receptors, dopaminergic, Ro10-5824, dihydrochloride, Tocris Bioscience, D4 Receptor Agonist products

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