WIN 55,212-3 mesylate
Cat. No. 2327
Alternative Name: (S)-(-)-WIN 55,212
Chemical Name: [(3S)-2,3-Dihydro-5-methyl-3-(4-mor
Biological ActivityNovel, low potency CB2 receptor silent antagonist and CB1 receptor partial inverse agonist. Competitively antagonizes effects of CP 55,940 (pA2 = 6.1) and SR 144528 (pEC50 = 5.3) at CB2 receptors and acts as a partial inverse agonist at CB1 receptors (pIC50 = 5.5). Displays modest activity at human melatonin MT1 and muscarinic M4 receptors, but is selective over several other GPCRs.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Savinainen et al (2005) Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. Br.J.Pharmacol. 145 636. PMID: 15852035.
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Citations are publications that use Tocris products. Selected citations for WIN 55,212-3 mesylate include:
Mereu et al (2003) Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release. Proc Natl Acad Sci U S A 100 4915. PMID: 12679519.
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Keywords: WIN 552,12-3 mesylate, supplier, CB2, antagonists, CB1, partial, inverse, agonists, cannabinoids, Non-Selective, Receptors, WIN552123, mesylate, (S)-(-)-WIN55212, cb2r, cb1r, Tocris Bioscience, Non-selective Cannabinoid Antagonist products
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Potent and selective CB2 partial agonist; orally biovailable
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