Cat. No. 0911

Glibenclamide C23H28ClN3O5S [10238-21-8]

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Alternative Name: Glyburide

Chemical Name: 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide

Biological Activity

ATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.

Technical Data

Soluble to 100 mM in DMSO and to 5 mM in ethanol
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Sheppard and Welsh (1992) Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels. J.Gen.Physiol. 100 573. PMID: 1281220.

Robertson et al (1990) Potassium channel modulators: scientific applications and therapeutic promise. J.Med.Chem. 33 1529. PMID: 2187993.

Brogden et al (1979) Glibenclamide: a review. Drugs 18 329. PMID: 389600.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Glibenclamide include:

Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Biomed Res Int 10 e0121634. PMID: 25803863.

Mehmood et al (2015) Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation. Neuroscience 15 75. PMID: 25886126.

Chen et al (2014) Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents. J Pharmacol Exp Ther 2014 182846. PMID: 24800210.

Jiang and Zsombok (2014) Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1. Front Neurosci 7 270. PMID: 24454277.

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. J Neurophysiol 8 e66404. PMID: 23799098.

Chung et al (2011) Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. J Korean Med Sci 106 2865. PMID: 21900507.

Quock et al (2011) The acute antinociceptive effect of HBO2 is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice. Brain Res 1368 102. PMID: 20977894.

Saloman et al (2011) Activation of peripheral δ-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats. PLoS One 190 379. PMID: 21664434.

He et al (2010) Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome. J Immunol 184 5743. PMID: 20393140.

Song et al (2010) Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts. PLoS One 25 380. PMID: 20191036.

Price et al (2008) Nesfatin-1 inhibits NPY neurons in the arcuate nucleus. Brain Res 1230 99. PMID: 18625211.

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Keywords: Glibenclamide, supplier, K+, channel, blockers, KATP, Blocks, CFTR, Cl-, channels, Potassium, KIR, Inward, Rectifier, Chloride, kir6, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Blocker products

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