Glibenclamide

Cat. No. 0911

Glibenclamide C23H28ClN3O5S [10238-21-8]

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Alternative Name: Glyburide

Chemical Name: 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide

Biological Activity

ATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.

Technical Data

M.Wt:
494
Formula:
C23H28ClN3O5S
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
10238-21-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Sheppard and Welsh (1992) Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels. J.Gen.Physiol. 100 573. PMID: 1281220.

Robertson et al (1990) Potassium channel modulators: scientific applications and therapeutic promise. J.Med.Chem. 33 1529. PMID: 2187993.

Brogden et al (1979) Glibenclamide: a review. Drugs 18 329. PMID: 389600.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Glibenclamide include:

Jiang and Zsombok (2014) Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1. Front Neurosci 7 270. PMID: 24454277.

Quock et al (2011) The acute antinociceptive effect of HBO2 is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice. Brain Res 1368 102. PMID: 20977894.

He et al (2010) Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome. J Immunol 184 5743. PMID: 20393140.

Price et al (2008) Nesfatin-1 inhibits NPY neurons in the arcuate nucleus. Brain Res 1230 99. PMID: 18625211.

Do you know of a great paper that uses Glibenclamide from Tocris? If so please let us know.show all ▼show less ▲

Keywords: Glibenclamide, supplier, K+, channel, blockers, KATP, Blocks, CFTR, Cl-, channels, Potassium, KIR, Inward, Rectifier, Chloride, kir6, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Blocker products

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