GBR 13069 dihydrochloride

Cat. No. 0420

GBR 13069 dihydrochloride C28H30F2N2O.2HCl [67469-45-8]

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Chemical Name: (1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride

Biological Activity

A potent inhibitor of dopamine uptake (IC50 = 40 nM). Centrally active following systemic administration in vivo.

Technical Data

Soluble to 5 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mayer et al (1986) Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport. J.Neurochem. 47 1073. PMID: 3489072.

Van der Zee and Hespe (1985) Interaction between substituted 1-[2-diphenylmethoxyethyl]piperazines and dopamine receptors. Neuropharmacology 24 1171. PMID: 4094653.

Heikkila et al (1984) Behavioural properties of GBR12909, GBR13069 and GBR13098: specific inhibitors of dopamine uptake. Eur.J.Pharmacol. 103 241. PMID: 6237922.

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