Cat. No. 2651
Chemical Name: 6-Phenylimidazo[2,1-b]-1,3,4-thiadi
Biological ActivityInhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Gallo (2006) Targeting HSP90 to halt neurodegeneration. Chem.Biol. 13 115. PMID: 16492558.
Salehi et al (2006) AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem.Biol. 13 213. PMID: 16492569.
If you know of a relevant reference for AEG 3482 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses AEG 3482 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: AEG 3482, supplier, inhibitors, inhibits, JNK, signaling, Mitogen-Activated, Protein, Kinases, c-Jun, N-Terminal, SAPKs, Stress-Activated, AEG3482, Tocris Bioscience, JNK/c-Jun Inhibitor products
Find multiple products by catalog number
New Products in this Area
High affinity JNK inhibitor; also inhibits HCMV replicationOrg 48762-0
Selective p38α/β inhibitor; orally bioavailable
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.