AEG 3482

Cat. No. 2651

AEG 3482 C10H8N4O2S2 [63735-71-7]

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Chemical Name: 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

Biological Activity

Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).

Technical Data

M.Wt:
280.33
Formula:
C10H8N4O2S2
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
63735-71-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Gallo (2006) Targeting HSP90 to halt neurodegeneration. Chem.Biol. 13 115. PMID: 16492558.

Salehi et al (2006) AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem.Biol. 13 213. PMID: 16492569.

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Keywords: AEG 3482, supplier, inhibitors, inhibits, JNK, signaling, Mitogen-Activated, Protein, Kinases, c-Jun, N-Terminal, SAPKs, Stress-Activated, AEG3482, Tocris Bioscience, JNK/c-Jun Inhibitor products

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