Cat. No. 2651
Chemical Name: 6-Phenylimidazo[2,1-b]-1,3,4-thiadi
Biological ActivityInhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gallo (2006) Targeting HSP90 to halt neurodegeneration. Chem.Biol. 13 115. PMID: 16492558.
Salehi et al (2006) AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem.Biol. 13 213. PMID: 16492569.
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Keywords: AEG 3482, supplier, inhibitors, inhibits, JNK, signaling, Mitogen-Activated, Protein, Kinases, c-Jun, N-Terminal, SAPKs, Stress-Activated, AEG3482, Tocris Bioscience, JNK/c-Jun Inhibitor products
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