GBR 12935 dihydrochloride

Cat. No. 0514

GBR 12935 dihydrochloride C28H34N2O.2HCl [67469-81-2]

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Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazine dihydrochloride

Biological Activity

Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).

Technical Data

M.Wt:
487.51
Formula:
C28H34N2O.2HCl
Solubility:
Soluble to 5 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
67469-81-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Reith et al (1994) GBR 12909 and 12935 block dopamine uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 253 175. PMID: 8013544.

Reith et al (1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter. Eur.J.Pharmacol. 227 417. PMID: 1446712.

Andersen et al (1987) Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the dopamine uptake complex. J.Neurochem. 48 1887. PMID: 2952763.

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Keywords: GBR 12935 dihydrochloride, supplier, Selective, dopamine, uptake, inhibitors, inhibits, DAT, Transporters, Monoamine, Neurotransmitter, GBR12935, dihydrochloride, Tocris Bioscience, Dopamine Transporter Inhibitor products

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