GBR 12935 dihydrochloride
Cat. No. 0514
Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phe
Biological ActivityPotent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Reith et al (1994) GBR 12909 and 12935 block dopamine uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 253 175. PMID: 8013544.
Reith et al (1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter. Eur.J.Pharmacol. 227 417. PMID: 1446712.
Andersen et al (1987) Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the dopamine uptake complex. J.Neurochem. 48 1887. PMID: 2952763.
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