Necrostatin-1

Cat. No. 2324

Necrostatin-1 C13H13N3OS [4311-88-0]

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Chemical Name: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

Biological Activity

ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.

Technical Data

M.Wt:
259.33
Formula:
C13H13N3OS
Solubility:
Soluble to 30 mM in DMSO and to 15 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
4311-88-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Linkermann et al (2012) Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. 81 751. PMID: 22237751.

Degterev et al (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat.Chem.Biol. 4 313. PMID: 18408713.

Degterev et al (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat.Chem.Biol. 1 112. PMID: 16408008.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Necrostatin-1 include:

Sagher et al (2014) The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells. Cancer Cell Int 14 75. PMID: 25324692.

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Keywords: Necrostatin-1, supplier, non-apoptotic, cell, death, necroptosis, Death, domain, receptor-associated, adaptor, RIP1, inhibits, inhibitors, Apoptosis, RIPK, RIPK1, receptor-interacting, protein, kinase, 1, other, kinases, Tocris Bioscience, Other Kinase Inhibitor products

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