DMPQ dihydrochloride

Cat. No. 1222

DMPQ dihydrochloride C16H14N2O2.2HCl [1123491-15-5]

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Chemical Name: 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride

Biological Activity

A potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.

Technical Data

M.Wt:
339.22
Formula:
C16H14N2O2.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
1123491-15-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Dolle et al (1994) 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase J.Med.Chem. 37 2627. PMID: 8064792.

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Citations are publications that use Tocris products.

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Keywords: DMPQ dihydrochloride, supplier, Potent, selective, inhibitors, inhibits, PDGFRβ, PDGFRbeta, PDGFRb, Platelet, Derived, Growth, Factors, Receptors, Receptor, Tyrosine, Kinases, RTKs, Tocris Bioscience, PDGFR Inhibitor products

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