(RS)-PPG

Cat. No. 1220

(RS)-PPG C8H10NO5P [120667-15-4]

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Chemical Name: (RS)-4-Phosphonophenylglycine

Biological Activity

A potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu8; anticonvulsant and neuroprotective in vivo. Also available as part of the Group III mGlu Receptor Tocriset™.

Technical Data

M.Wt:
231.14
Formula:
C8H10NO5P
Solubility:
Soluble to 100 mM in 1eq. NaOH
Storage:
Store at RT
CAS No:
120667-15-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Gasparini et al (1999) (R,S)-4-Phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J.Pharmacol.Exp.Ther. 289 1678. PMID: 10336568.

Flor et al (1998) Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist. Soc.Neurosci.Abstr. 24 431.11.

Bigge et al (1989) Exploration of phenyl-spaced 2-amino-(5,9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists. J.Med.Chem. 32 1580. PMID: 2544728.

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Keywords: (RS)-PPG, supplier, Potent, selective, mGlu8, mGluR8, agonist, Group, III, Receptors, Glutamate, Metabotropic, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Agonist products

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