GBR 12783 dihydrochloride

Cat. No. 0513

GBR 12783 dihydrochloride C28H32N2O.2HCl [67469-75-4]

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Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride

Biological Activity

A very potent and selective inhibitor of dopamine uptake (IC50 for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).

Technical Data

Soluble to 10 mM in water with gentle warming
>99 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Do-Rego et al (1999) Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of dopamine. J.Neurochem. 72 396. PMID: 9886093.

Giros et al (1992) Cloning, pharmacological characterization and chromosome assignment of the human dopamine transporter. Mol.Pharmacol. 42 383. PMID: 1406597.

Vaugeois et al (1992) In vivo labelling of the neuronal dopamine uptake complex in the mouse striatum by [3H]GBR 12783. Eur.J.Pharmacol. 210 77. PMID: 1350989.

Bonnet and Constentin (1986) GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo. Eur.J.Pharmacol. 121 199. PMID: 3754516.

If you know of a relevant reference for GBR 12783 dihydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for GBR 12783 dihydrochloride include:

Ferraro et al (2012) A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology 37 1856. PMID: 22453136.

Ferreira et al (2012) Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences. J Pharmacol Exp Ther 61 219. PMID: 22609378.

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