BTS 54-505 hydrochloride
Cat. No. 2322
Chemical Name: 1-(4-Chlorophenyl)-α-(2-methylpropyl
Biological ActivityPotently active primary amine metabolite of sibutramine (Cat. No. 2290), exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro. Reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis in vivo.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Liu et al (2002) Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine. Int.J.Obes.Relat.Metab.Disord. 26 1245. PMID: 12187403.
Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581. PMID: 9353373.
Luscombe et al (1989) The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology 28 129. PMID: 2541365.
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