EHNA hydrochloride

Cat. No. 1261

EHNA hydrochloride C14H23N5O.HCl [58337-38-5]

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Chemical Name: erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride

Biological Activity

Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase. Suppresses spontaneous differentiation of human ESCs in feeder-free conditions. Also prevents directed neuronal differentiation.

Technical Data

M.Wt:
313.83
Formula:
C14H23N5O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
58337-38-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Michie et al (1996) Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T-cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell.Signal. 8 97. PMID: 8730511.

Podzuweit et al (1995) Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl)adenine. Cell.Signal. 7 733. PMID: 8519602.

Bessodes et al (1982) Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition. Biochem.Pharmacol. 31 879. PMID: 7082355.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for EHNA hydrochloride include:

Davidson et al (2016) Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass PLoS One 11 e0158981. PMID: 27384524.

Guerrero et al (2013) Induction of 8,5'-cyclo-2'-deoxyadenosine and 8,5'-cyclo-2'-deoxyguanosine in isolated DNA by Fenton-type reagents. Chem Res Toxicol 26 1361. PMID: 23961697.

Takahashi et al (2010) Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats. Br J Pharmacol 161 1806. PMID: 20735412.

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View Related Products by Product Action

Keywords: EHNA hydrochloride, supplier, PDE2, inhibitors, inhibits, adenosines, deaminases, Phosphodiesterases, Tocris Bioscience, Deaminase Inhibitor products

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