Cat. No. 2321
Alternative Name: Calcium-like peptide 3
Biological ActivityCell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site. Activates phosphodiesterase in the absence of Ca2+ and inhibits Ca2+-mediated cytotoxicity and apoptosis (IC50 = 33 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ten Broeke et al (2003) Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. Eur.J.Pharmacol. 476 151. PMID: 12969760.
Manion et al (2000) A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14 1297. PMID: 10877822.
Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676.
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Keywords: CALP3, supplier, Cell-permeable, calmodulin, agonists, Ca2+, Binding, Protein, modulators, Calmodulin, Calcium, Signaling, Signalling, Calcium-like, peptide3, Tocris Bioscience, Calcium Binding Protein Modulator Agonist products
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