Cat. No. 2319
Alternative Name: Calcium-like peptide 2
Biological ActivityCell-permeable calmodulin (CaM) antagonist that binds to the EF-hand/Ca2+-binding site. CALP2 has been demonstrated to inhibit CaM-dependant phosphodiesterase activity and increase intracellular Ca2+ concentrations by modulating Ca2+-channel activity. CALP2 has also been shown to be a potent activator of alveolar macrophages.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ten Broeke et al (2004) Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab.Invest. 84 29. PMID: 14631377.
Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861. PMID: 11145661.
Ten Broeke et al (2001) Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 15 1831. PMID: 11481245.
Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676.
If you know of a relevant reference for CALP2 please let us know.
Citations are publications that use Tocris products. Selected citations for CALP2 include:
Heo et al (2015) Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells. Sci Rep 5 16895. PMID: 26592929.
Fernández-Velasco et al (2011) RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice. PLoS One 6 e20863. PMID: 21673970.
Do you know of a great paper that uses CALP2 from Tocris? If so please let us know.
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Keywords: CALP2, supplier, Cell-permeable, calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Calcium-like, peptide2, Tocris Bioscience, Calcium Binding Protein Modulator Antagonist products