β-Funaltrexamine hydrochloride

Cat. No. 0926

b-Funaltrexamine hydrochloride C25H30N2O6.HCl [72786-10-8]

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Alternative Name: β-FNA

Chemical Name: (E)-4-[[5α,6β)-17-Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-butenoicacid methyl ester hydrochloride

Biological Activity

Selective μ opioid receptor antagonist.

Licensing Information

Sold with the permission of the University of Minnesota

Technical Data

M.Wt:
490.99
Formula:
C25H30N2O6.HCl
Solubility:
Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
72786-10-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Jiang et al (1990) μ Antagonist and κ agonist properties of β-funaltrexamine (β-FNA) in vivo: long lasting spinal analgesia in mice. J.Pharmacol.Exp.Ther. 252 1006. PMID: 2156986.

Takemorei et al (1981) The irreversible narcotic antagonist and reversible agonist properties of the fumarate methyl ester derivative of naltrexone. Eur.J.Pharmacol. 70 445. PMID: 6263637.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for β-Funaltrexamine hydrochloride include:

Tzeng et al (2011) Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. Evid Based Complement Alternat Med 2011 150752. PMID: 21785619.

Largent-Milnes et al (2010) Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. Br J Pharmacol 161 986. PMID: 20977451.

Cecchi et al (2008) Differential responses to morphine-induced analgesia in the tail-flick test. Behav Brain Res 194 146. PMID: 18656501.

Do you know of a great paper that uses β-Funaltrexamine hydrochloride from Tocris? If so please let us know.

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