Pravastatin sodium salt

Cat. No. 2318

Pravastatin sodium salt C23H35NaO7 [81131-70-6]

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Alternative Name: Eptastatin sodium

Chemical Name: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid monosodium salt

Biological Activity

Water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties.

Technical Data

M.Wt:
446.51
Formula:
C23H35NaO7
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
81131-70-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hamelin and Turgeon (1998) Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. TiPS 19 26. PMID: 9509899.

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Citations are publications that use Tocris products. Selected citations for Pravastatin sodium salt include:

Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. Proc Natl Acad Sci U S A 2 1176. PMID: 22202492.

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Keywords: Pravastatin sodium salt, supplier, HMG-CoA, reductases, inhibitors, inhibits, Tocris Bioscience, HMG-CoA Reductase Inhibitor products

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