LOE 908 hydrochloride

Cat. No. 2314

LOE 908 hydrochloride C41H48N2O9.HCl [143482-60-4]

Price and Availability

For LOE 908 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamide hydrochloride

Biological Activity

Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na+ and K+ channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.

Technical Data

M.Wt:
749.29
Formula:
C41H48N2O9.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
143482-60-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Christensen et al (2005) The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin.Pharmacol.Toxicol. 96 316. PMID: 15755315.

Tatlisumak et al (2000) Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat. J.Neurol.Sci. 178 107. PMID: 11018702.

Krause et al (1998) LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture. Biochem.Biophys.Res.Comm. 244 659. PMID: 9535721.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for LOE 908 hydrochloride include:

Varadarajan et al (2013) Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PLoS One 8 e56603. PMID: 23457590.

Harper and Poole (2010) Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets. J Biol Chem 285 19865. PMID: 20388711.

Do you know of a great paper that uses LOE 908 hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: LOE 908 hydrochloride, supplier, Broad, spectrum, cation, channels, blockers, neuroprotective, modulators, VDAC, store-operated, calcium, SOCs, voltage-operated, VOCs, non-selective, NSCCs, LOE908, hydrochloride, Tocris Bioscience, Other Channel Modulator products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area

Ani 9

Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker

MONNA

Potent TMEM16A (Anoctamin-1) blocker

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.