QX 314 chloride

Cat. No. 2313

QX 314 chloride C16H27N2OCl [5369-03-9]

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Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.

Technical Data

M.Wt:
298.85
Formula:
C16H27N2OCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
5369-03-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Perkins and Wong (1995) Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 72 911.

Alreja and Aghajanian (1994) QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain Res. 639 320. PMID: 8205485.

Stichartz et al (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 62 37. PMID: 4541340.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for QX 314 chloride include:

Cunningham et al (2014) hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell 15 559. PMID: 25517465.

Wang et al (2006) Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron 50 443. PMID: 16675398.

Do you know of a great paper that uses QX 314 chloride from Tocris? If so please let us know.

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Keywords: QX 314 chloride, supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX314, chloride, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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