4F 4PP oxalate
Cat. No. 0523
Chemical Name: 4-(4-Fluorobenzoyl)-1-(4-phenylbuty
Biological ActivityA selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki = 620 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Hagberg et al (1998) Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels. Neurochem.Int. 32 153. PMID: 9542727.
Herndon et al (1992) Ketanserin analogues - structure affinity relationships of 5HT2 and 5HT1C serotonin receptor binding. J.Med.Chem. 35 4903. PMID: 1479590.
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Citations are publications that use Tocris products. Selected citations for 4F 4PP oxalate include:
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.
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Keywords: 4F 4PP oxalate, supplier, Selective, 5-HT2A, antagonists, Serotonin, Receptors, 5-HT2, 4F4PP, oxalate, Tocris Bioscience, 5-HT2A Receptor Antagonist products