4F 4PP oxalate

Cat. No. 0523

4F 4PP oxalate C22H26FNO.C2H2O4 [144734-36-1]

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Chemical Name: 4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine oxalate

Biological Activity

A selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki = 620 nM).

Technical Data

M.Wt:
429.49
Formula:
C22H26FNO.C2H2O4
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
144734-36-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hagberg et al (1998) Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels. Neurochem.Int. 32 153. PMID: 9542727.

Herndon et al (1992) Ketanserin analogues - structure affinity relationships of 5HT2 and 5HT1C serotonin receptor binding. J.Med.Chem. 35 4903. PMID: 1479590.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 4F 4PP oxalate include:

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.

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Keywords: 4F 4PP oxalate, supplier, Selective, 5-HT2A, antagonists, Serotonin, Receptors, 5-HT2, 4F4PP, oxalate, Tocris Bioscience, 5-HT2A Receptor Antagonist products

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