Cat. No. 2309
Chemical Name: 2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[
Biological ActivityPotent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Marie-Claire et al (2008) Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice. Neuropharmacology 54 1107. PMID: 18410947.
Quere et al (1998) X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist. Bioorg.Med.Chem.Lett. 8 653. PMID: 9871577.
Gully et al (1997) Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J.Pharmacol.Exp.Ther. 280 802. PMID: 9023294.
If you know of a relevant reference for SR 142948 please let us know.
Citations are publications that use Tocris products. Selected citations for SR 142948 include:
Rouibi et al (2016) Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyrneurotensin. J Cereb Blood Flow Metab 9 470. PMID: 26733785.
Piccart et al (2015) Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci 35 11144. PMID: 26245975.
Yin et al (2008) Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. Neuropharmacology 54 79. PMID: 17675102.
Do you know of a great paper that uses SR 142948 from Tocris? If so please let us know.
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Keywords: SR 142948, supplier, potent, NT, receptor, antagonists, Receptors, Neurotensin, SR142948, Tocris Bioscience, Neurotensin Receptor Antagonist products
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