SR 142948

Cat. No. 2309

SR 142948 C39H51N5O6 [184162-64-9]

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Chemical Name: 2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid

Biological Activity

Potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.

Technical Data

M.Wt:
685.86
Formula:
C39H51N5O6
Solubility:
Soluble to 75 mM in DMSO and to 25 mM in water
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
184162-64-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Marie-Claire et al (2008) Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice. Neuropharmacology 54 1107. PMID: 18410947.

Quere et al (1998) X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist. Bioorg.Med.Chem.Lett. 8 653. PMID: 9871577.

Gully et al (1997) Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J.Pharmacol.Exp.Ther. 280 802. PMID: 9023294.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SR 142948 include:

Piccart et al (2015) Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci 35 11144. PMID: 26245975.

Yin et al (2008) Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. Neuropharmacology 54 79. PMID: 17675102.

Do you know of a great paper that uses SR 142948 from Tocris? If so please let us know.

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Keywords: SR 142948, supplier, potent, NT, receptor, antagonists, Receptors, Neurotensin, SR142948, Tocris Bioscience, Neurotensin Receptor Antagonist products

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