Cat. No. 0522
Chemical Name: (E)-1-[Bis(4-fluorophenyl)methyl]-4
Biological ActivityDual Na+/Ca2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Urenjak and Obrenovitch (1996) Pharmacological modulation of voltage gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol.Rev. 48 21. PMID: 8685246.
Eichler et al (1994) The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after axotomy. J.Neurochem. 62 2148. PMID: 8189223.
Pauwels et al (1991) Ca+ and Na+ channels involved in neuronal cell death - protection by flunarizine. Life.Sci. 48 1881. PMID: 1850815.
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Keywords: Flunarizine dihydrochloride, supplier, Dual, Na+/Ca2+, channel, T-type, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Na+, Calcium, CaV, Ca2+, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products