Cat. No. 2308
Alternative Name: NN 703
Chemical Name: N-[(2E)-5-Amino-5-methyl-1-oxo-2-he
Biological ActivityPotent, orally active ghrelin receptor (GHS-R1a) agonist (Ki = 50 nM at human recombinant GHS-R1a). Stimulates GH release from rat pituitary cells with an EC50 value of 2.7 nM. Induces hyperphagia and adiposity in lean rats, but not in leptin signaling-deficient ZDF rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Holm et al (2004) Adipogenic and orexigenic effects of the ghrelin-receptor ligand tabimorelin are diminished in leptin-signalling-deficient ZDF rats. Eur.J.Pharmacol. 150 893.
Hansen et al (1999) Pharmacological characterisation of a new oral GH secretagogue, NN703. Eur.J.Endocrinol. 141 180. PMID: 10427162.
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Keywords: Tabimorelin hemifumarate, supplier, Potent, orally, active, ghrelin, receptor, agonists, GHS-R1a, Receptors, Growth, Hormone, Secretagog, 1a, NN703, Tocris Bioscience, Ghrelin Receptor Agonist products
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