Leukotriene B4

Cat. No. 2307

Leukotriene B4 C20H32O4 [71160-24-2]

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Alternative Names: LTB4, 5,12-DiHETE

Chemical Name: (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid

Biological Activity

Potent lipid inflammatory mediator derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Binds to BLT1 and BLT2 receptors and acts as a potent chemotactic agent and activator of leukocytes. Also displays antiviral activity towards DNA viruses and retroviruses.

Technical Data

M.Wt:
336.47
Formula:
C20H32O4
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 50g/ml)
Storage:
Store at -20°C
CAS No:
71160-24-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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Yokomitso et al (2001) Leukotriene B4: metabolism and signal transduction. Arch.Biochem.Biophys. 385 231. PMID: 11368003.

Ford-Hutchinson (1990) Leukotriene B4 in inflammation. Crit.Rev.Immunol. 10 1. PMID: 2155000.

Bray et al (1981) Leukotriene B4: an inflammatory mediator in vivo. Prostaglandins 22 213. PMID: 6270742.

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Keywords: Leukotriene B4, supplier, BLT1, BLT2, receptor, agonists, potent, Receptors, leukotrienes, eicosanoids, LeukotrieneB4, Tocris Bioscience, Leukotriene and Related Receptor Agonist products

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