Cat. No. 2305

Tautomycetin C33H50O10 [119757-73-2]

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Chemical Name: (1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester

Biological Activity

Selective inhibitor of protein phosphatase (PP)1 (IC50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.

Technical Data

Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
>95 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kim et al (2005) Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells. Transplant Proc. 37 1959. PMID: 15919517.

Shim et al (2002) Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc.Natl.Acad.Sci.USA. 99 10617. PMID: 12149481.

Mitsuhashi et al (2001) Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. Biochem.Biophys.Res.Comm. 287 328. PMID: 11554729.

If you know of a relevant reference for Tautomycetin please let us know.

Citations are publications that use Tocris products. Selected citations for Tautomycetin include:

Engmann et al (2015) DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nat Commun 6 10099. PMID: 26639316.

Hégarat et al (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. Anticancer Res 10 e1004004. PMID: 24391510.

Isensee et al (2014) Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci 127 216. PMID: 24190886.

Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. PLoS Genet 7 62. PMID: 25071439.

Pribiag and Stellwagen (2013) TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors. Front Neurosci 33 15879. PMID: 24089494.

Walsh and Young (2011) TGF-β regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1. Anticancer Res 31 3159. PMID: 21965722.

Walsh and Young (2010) Interrelationship between protein phosphatase 1 and TGF-{β} in regulating motility and cytoskeletal architecture of endothelial cells. J Neurosci 30 4861. PMID: 21187463.

Do you know of a great paper that uses Tautomycetin from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Tautomycetin, supplier, Selective, PP1, inhibitors, inhibits, Calcineurin, Protein, Ser/Thr, Phosphatases, immunosuppressants, transplant, PP2, TC, Tocris Bioscience, Protein Ser/Thr Phosphatases Inhibitor products

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