Cat. No. 0658
Chemical Name: N,N-Dihexyl-2-(4-fluorophenyl)indol
Biological ActivityBinds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC50 = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kozikowski et al (1992) Synthesis of (2-arylindol-3-yl)acetamides as probes for mitochondrial steroidogenesis - a new mechanism of GABAA receptor modulation. Angew.Chem.Int.Ed. 31 1060.
Romeo et al (1992) 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J.Pharmacol.Exp.Ther. 262 971. PMID: 1326631.
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Citations are publications that use Tocris products. Selected citations for FGIN-1-27 include:
Sutter et al (2003) Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. Glia 89 564. PMID: 12888831.
Do you know of a great paper that uses FGIN-1-27 from Tocris? If so please let us know.
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Keywords: FGIN-1-27, supplier, Potent, specific, ligand, mitochondrial, DBI, receptor, GABAA, Receptors, FGIN127, Tocris Bioscience, Translocator Protein products
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