FGIN-1-27

Cat. No. 0658

FGIN-1-27 C28H37FN2O [142720-24-9]

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Chemical Name: N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide

Biological Activity

Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC50 = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.

Technical Data

M.Wt:
436.61
Formula:
C28H37FN2O
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
142720-24-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kozikowski et al (1992) Synthesis of (2-arylindol-3-yl)acetamides as probes for mitochondrial steroidogenesis - a new mechanism of GABAA receptor modulation. Angew.Chem.Int.Ed. 31 1060.

Romeo et al (1992) 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J.Pharmacol.Exp.Ther. 262 971. PMID: 1326631.

If you know of a relevant reference for FGIN-1-27 please let us know.

Citations are publications that use Tocris products. Selected citations for FGIN-1-27 include:

Sutter et al (2003) Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. Glia 89 564. PMID: 12888831.

Do you know of a great paper that uses FGIN-1-27 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: FGIN-1-27, supplier, Potent, specific, ligand, mitochondrial, DBI, receptor, GABAA, Receptors, FGIN127, Tocris Bioscience, Translocator Protein products

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