Cat. No. 0869
Chemical Name: 2-Phenyl-1,3-propanedioldicarbamate
Biological ActivityAnticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Coffin et al (1994) Selective antagonism of the anticonvulsant effects of felbamate by glycine. Eur.J.Pharmacol. 256 R9. PMID: 8050461.
De Sarro et al (1994) Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice. Eur.J.Pharmacol. 262 11. PMID: 7529182.
Serra et al (1994) Felbamate antagonises isoniazid- and FG7142-induced reduction of GABAA receptor function in the mouse brain. Eur.J.Pharmacol. 265 185. PMID: 7875235.
Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456. PMID: 7886818.
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Keywords: Felbamate, supplier, NMDA, antagonist, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products