Sanguinarine chloride

Cat. No. 2302

Sanguinarine chloride C20H14ClNO4 [5578-73-4]

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Chemical Name: 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride

Biological Activity

Inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1 phase; inhibits cell growth in human prostate carcinoma cells.

Technical Data

M.Wt:
367.78
Formula:
C20H14ClNO4
Solubility:
Soluble to 10 mM in DMSO
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
5578-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Aburai et al (2010) Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. Biosci.Biotechnol.Biochem. 74 548. PMID: 20208361.

Vogt et al (2005) The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1. J.Biol.Chem. 280 19078. PMID: 15753082.

Adhami et al (2004) Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol.Cell Ther. 3 934.

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Citations are publications that use Tocris products. Selected citations for Sanguinarine chloride include:

Kenny et al (2015) Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. PLoS One 6 6220. PMID: 25653139.

Bavaria et al (2014) The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis. Apoptosis 19 467. PMID: 24253595.

Candas et al (2014) Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells. Cancer Res 74 7498. PMID: 25377473.

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Keywords: Sanguinarine chloride, supplier, proapoptotic, anti-inflammatory, antioxidant, MKP-1, mitogen-activated, protein, kinase, phosphatase, inhibitors, blocks, cell, cycle, inhibits, protein, phosphase, 2C, PP2C, Tocris Bioscience, Protein Ser/Thr Phosphatases Inhibitor products

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