T 0070907

Cat. No. 2301

T 0070907 C12H8N3O3Cl [313516-66-4]

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Chemical Name: 2-Chloro-5-nitro-N-4-pyridinylbenzamide

Biological Activity

Potent and selective PPARγ antagonist (IC50 = 1 nM). Displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. Blocks transcriptional activity of PPARγ in vitro and inhibits rosiglitazone-induced adipogenesis.

Technical Data

M.Wt:
277.67
Formula:
C12H8N3O3Cl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
>99 %
Storage:
Store at RT
CAS No:
313516-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Schaefer et al (2005) Peroxisome proliferator-activated receptor γ inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells. Cancer Res. 65 2251. PMID: 15781638.

Rockwell and Kaminski (2004) A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J.Pharmacol.Exp.Ther. 311 683. PMID: 15284281.

Lee et al (2002) T0070907, a selective ligand for peroxisome proliferator-activated receptor γ, functions as an antagonist of biochemical and cellular activities. J.Biol.Chem. 277 19649. PMID: 11877444.

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Citations are publications that use Tocris products. Selected citations for T 0070907 include:

Bullers et al (2014) The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A 20 2390. PMID: 24548290.

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Keywords: T 0070907, supplier, potent, selective, PPARγ, PPARgamma, antagonists, Peroxisome, Proliferator-activating, Receptors, T0070907, Tocris Bioscience, PPARγ Antagonist products

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