Cat. No. 2297
Chemical Name: (11α,13E)-(-)-11,16-Dihydroxy-16-met
Biological ActivityCytoprotective prostaglandin E1 analog that displays agonist activity at EP receptors. Ki values are 120, 250, 67 and 67 nM at cloned mouse EP1, EP2, EP3 and EP4 receptors respectively. Prevents NSAID-induced gastric ulceration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kiriyama et al (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 122 217. PMID: 9313928.
Smith et al (1994) Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus. J.Pharmacol.Exp.Ther. 271 390. PMID: 7965740.
Graham et al (1988) Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. Lancet 2 1277. PMID: 2904006.
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Keywords: Misoprostol, supplier, Cytoprotective, PGE1, EP1, EP2, EP3, EP4, Receptors, Prostanoid, prostaglandins, prostacyclins, eicosanoids, Tocris Bioscience, Prostanoid Receptor Agonist products
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