Cat. No. 2296
Chemical Name: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-o
Biological ActivityEndogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP1, EP2, EP3 and EP4 receptors (Kd values range between ~ 1 - 10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
North et al (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447 1007. PMID: 17581586.
Hata and Breyer (2004) Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharm.Ther. 103 147.
Coleman et al (1994) Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol.Rev. 46 205. PMID: 7938166.
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Citations are publications that use Tocris products. Selected citations for Prostaglandin E2 include:
Drost et al (2016) Organoid culture systems for prostate epithelial and cancer tissue. Proc Natl Acad Sci U S A 11 347. PMID: 26797458.
Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Nat Protoc 148 126. PMID: 25307862.
Boj et al (2015) Organoid models of human and mouse ductal pancreatic cancer. Sci Signal 160 324. PMID: 25557080.
Gonnermann et al (2015) Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity. Oncoimmunology 4 e988460. PMID: 25949900.
Weeber et al (2015) Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases. Cell 112 13308. PMID: 26460009.
Anneken et al (2013) MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase. Respir Res 8 58. PMID: 23179355.
Wang et al (2012) Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. J Neuroimmune Pharmacol 5 ra26. PMID: 22472648.
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Keywords: Prostaglandin E2, supplier, endogenous, prostanoid, EP1, EP2, EP3, EP4, Receptors, prostaglandins, prostacyclins, eicosanoids, ProstaglandinE2, stem, cells, e2, Tocris Bioscience, Prostanoid Receptor Agonist products
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