Cat. No. 1249
Chemical Name: (-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexah
Biological ActivityCentrally active dopamine D1 receptor agonist, selective over D2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. Unlike SKF 38393 (Cat. No. 0922), it exerts antiParkinsonian activity in animal models.
Licensing InformationSold with the permission of Novartis Pharma AG
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Andersen and Jansen (1990) Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy. Eur.J.Pharmacol. 188 335. PMID: 1973652.
Temlett et al (1989) Antiparkinsonian activity of CY 208-243, a partial D-1 dopamine receptor agonist, in MPTP-treated marmosets and patients with Parkinson's disease. Mov.Disord. 4 261. PMID: 2571082.
Markstein et al (1988) Pharmacologic properties of CY 208-243, a novel D1 agonist. Progress in Catecholamine Research. Part B. Centra 59-64.
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Keywords: CY 208-243, supplier, Selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, CY208-243, Tocris Bioscience, D1 and D5 Receptor Agonist products
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