Cat. No. 2291
Alternative Name: NSC 7908
Chemical Name: 1,2,3,4,5,6-Hexabromocyclohexane
Biological ActivityPotently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Sandberg et al (2005) Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation. J.Med.Chem. 48 2526. PMID: 15801842.
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Citations are publications that use Tocris products. Selected citations for 1,2,3,4,5,6-Hexabromocyclohexane include:
Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Genes Dev 10 e0143319. PMID: 26619345.
Do you know of a great paper that uses 1,2,3,4,5,6-Hexabromocyclohexane from Tocris? If so please let us know.
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Keywords: 1,2,3,4,5,6-Hexabromocyclohexane, supplier, inhibitors, inhibits, JAK2, autophosphorylation, Kinases, Janus, Activated, NSC7908, Tocris Bioscience, JAK Inhibitor products
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