Sibutramine hydrochloride

Cat. No. 2290

Sibutramine hydrochloride C17H26NCl.HCl [84485-00-7]

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Alternative Name: BTS 54-524

Chemical Name: 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride

Biological Activity

5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.

Technical Data

M.Wt:
316.31
Formula:
C17H26NCl.HCl
Solubility:
Soluble to 5 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
84485-00-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581. PMID: 9353373.

Jackson et al (1997) Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 121 1758. PMID: 9283714.

Buckett et al (1988) The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat. 12 575.

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Keywords: Sibutramine hydrochloride, supplier, 5-HT, noradrenalin, reuptake, inhibitors, inhibits, SNRI, Noradrenalin, Transporter, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, BTS54524, noradrenaline, Tocris Bioscience, 5-HT Transporter Inhibitor products

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