Cat. No. 2290
Alternative Name: BTS 54-524
Chemical Name: 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2
Biological Activity5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581. PMID: 9353373.
Jackson et al (1997) Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 121 1758. PMID: 9283714.
Buckett et al (1988) The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat. 12 575.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Sibutramine hydrochloride include:
Yoshida et al (2015) Study on health hazards through medicines purchased on the Internet: a cross-sectional investigation of the quality of anti-obesity medicines containing crude drugs as active ingredients. PLoS One 15 430. PMID: 26637485.
Do you know of a great paper that uses Sibutramine hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Sibutramine hydrochloride, supplier, 5-HT, noradrenalin, reuptake, inhibitors, inhibits, SNRI, Noradrenalin, Transporter, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, BTS54524, noradrenaline, Tocris Bioscience, 5-HT Transporter Inhibitor products
Find multiple products by catalog number
New Products in this Area
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.