Cat. No. 2289
Chemical Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazi
Biological ActivityWater-soluble salt of lamotrigine (Cat. No. 1611). Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Grunze et al (1998) Modulation of calcium and potassium currents by lamotrigine. Neuropsychobiology 38 131. PMID: 9778600.
Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522. PMID: 9184596.
Smith and Meldrum (1995) Cardioprotective effect of lamotrigine after focal ischemia in rats. Stroke 26 117. PMID: 7839380.
Leach et al (1991) Neurochemical and behavioral aspects of lamotrigine. Epilepsia 32 S4. PMID: 1685439.
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Keywords: Lamotrigine isethionate, supplier, inhibitors, inhibits, glutamate, release, Receptors, GlaxoSmithKline, GSK, Tocris Bioscience, Miscellaneous Glutamate products