EBPC

Cat. No. 0518

EBPC C14H15NO4 [4450-98-0]

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Chemical Name: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

Biological Activity

Potent aldose reductase inhibitor. Improves the cytotoxicity of anticancer reagents such as cisplatin (Cat.No. 2251) and doxorubicin (Cat.No. 2252) in HeLa cervical carcinoma cells through an increase in ERK activity.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
261.28
Formula:
C14H15NO4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
4450-98-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kyoung et al (2002) Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases. Anti-cancer Drugs 13 859. PMID: 12394272.

Mylari et al (1991) A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate and its congeners. J.Med.Chem. 34 1011. PMID: 1900532.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for EBPC include:

Seo et al (2014) Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs. Pharmacol Res Perspect 90 99. PMID: 24695626.

Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98. PMID: 22654757.

Do you know of a great paper that uses EBPC from Tocris? If so please let us know.

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Keywords: EBPC, supplier, Aldose, reductase, inhibitors, inhibits, Reductases, Carbohydrate, Metabolism, Pfizer, Tocris Bioscience, Aldose Reductase Inhibitor products

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