Cat. No. 0518
Chemical Name: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole
Biological ActivityPotent aldose reductase inhibitor. Improves the cytotoxicity of anticancer reagents such as cisplatin (Cat.No. 2251) and doxorubicin (Cat.No. 2252) in HeLa cervical carcinoma cells through an increase in ERK activity.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kyoung et al (2002) Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases. Anti-cancer Drugs 13 859. PMID: 12394272.
Mylari et al (1991) A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate and its congeners. J.Med.Chem. 34 1011. PMID: 1900532.
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Citations are publications that use Tocris products. Selected citations for EBPC include:
Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98. PMID: 22654757.
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Keywords: EBPC, supplier, Aldose, reductase, inhibitors, inhibits, Reductases, Carbohydrate, Metabolism, Pfizer, Tocris Bioscience, Aldose Reductase Inhibitor products
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