Cat. No. 2287
Alternative Name: Staurosporinone
Chemical Name: 6,7,12,13-Tetrahydro-5H-indolo[2,3-
Biological ActivityInhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
McGovern and Shoichet (2003) Kinase inhibitors: not just for kinases anymore. J.Med.Chem. 46 1478. PMID: 12672248.
Zimmermann et al (2000) Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 48 49. PMID: 11080540.
Fabre et al (1993) Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg.Med.Chem. 1 193. PMID: 8081852.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for K-252c include:
Goldman et al (2012) An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chem Biol 19 855. PMID: 22840773.
Do you know of a great paper that uses K-252c from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: K-252c, supplier, Protein, kinases, C, inhibitors, inhibits, PKC, Tocris Bioscience, Protein Kinase C Inhibitor products
Find multiple products by catalog number
New Products in this Area
MSK/RSK family kinase inhibitorLTURM 34
Potent DNA-PK inhibitorMLi-2
Potent and selective LRRK2 inhibitorLTURM 36
PI 3-kinase δ inhibitorPI 3065
Potent and selective PI 3-kinase p110δ inhibitorAZ PFKFB3 67
Potent and selective PFKFB3 inhibitorSTOCK2S 26016
Lysine deficient protein kinase (WNK) signaling inhibitorrac-CCT 250863
Potent Nek2 inhibitorRoscovitine
Potent, selective cyclin-dependent kinase inhibitorEnzastaurin
Potent PKCβ inhibitorBMS 265246
Potent cdk1/2 inhibitorAutocamtide-2-related inhibitory peptide, myristoylated
CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptideMP A08
Selective ATP competitive SphK1 and 2 inhibitor; cell permeableAkti-1/2
Potent and selective dual Akt1 and 2 inhibitor
One Day Symposium
March 1, 2017
Amsterdam, The Netherlands