K-252c

Cat. No. 2287

K-252c C20H13N3O [85753-43-1]

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Alternative Name: Staurosporinone

Chemical Name: 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one

Biological Activity

Inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).

Technical Data

M.Wt:
311.34
Formula:
C20H13N3O
Solubility:
Soluble to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
85753-43-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

McGovern and Shoichet (2003) Kinase inhibitors: not just for kinases anymore. J.Med.Chem. 46 1478. PMID: 12672248.

Zimmermann et al (2000) Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 48 49. PMID: 11080540.

Fabre et al (1993) Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg.Med.Chem. 1 193. PMID: 8081852.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for K-252c include:

Goldman et al (2012) An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chem Biol 19 855. PMID: 22840773.

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Keywords: K-252c, supplier, Protein, kinases, C, inhibitors, inhibits, PKC, Tocris Bioscience, Protein Kinase C Inhibitor products

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